Position:
Chair of Infection Medicine-University of Edinburgh, Head of Centre- Centre for Inflammation Research/Institute of Regeneration and Repair, Co-director Edinburgh Infectious Diseases
Research Interests:
Innate immune responses to infection and regulation of inflammation
Microbicidal mechanisms against bacterial infection
Host based strategies to combat antimicrobial resistence
One Health approaches to infectious diseases
HIV medicine and infections in immunocompromised hosts
Projects/ grants:
The SHIELD Consortium (The Universities of SHeffield, Edinburgh, BIrmingham and Newcastle Led Partnership to Develop Host Defence Therapeutics) Optimising Innate Host Defence to Combat Antimicrobial Resistance PI Dockrell December 2016-23 £ 3,592,676 MR/N02995X/1
Medical Research Foundation National PhD Training Programme in Antimicrobial Resistance PI M. Avison (Co-I A. Bailey, D. Crook, D. Dockrell, C. Dowson, M. Holmes, A. Singer, D. Stekel and C. Walti) Sept 2017- Dec 2022. £2, 451,007. MRF-145-0004-TPG-AVISO
CSO Scotland Covid UoE Portfolio (lead) COV/EDI/20/4, 10, 11, 12, 13, 16, 17, 18) 2020-21 £603,500
UKRI-MRC Programme Grant (MICA) Mitochondrial dysfunction in macrophages and impaired bacterial clearance in chronic obstructive pulmonary disease (COPD) PI D Dockrell December 2022-27 £1,938,359 MR/W028506/1
https://www.ed.ac.uk/inflammation-research
https://www.ed.ac.uk/inflammation-research/people/principal-investigators/professor-david-dockrell
Background:
David’s research interest has focused on pathogenesis of infectious disease and mechanism of susceptibility. He has in particular promoted studies to identify mechanism that can be exploited as host based therapy to combat antimicrobial resistance and severe viral infections. David is part of the management group for the national doctoral training programme in antimicrobial resistance. He helps co-ordinate infection activities through the university through his roles in the Centre for Inflammation Research and Edinburgh Infectious Diseases
Key Publications:
2023
NRF2 Activation Reprogrammes Defects in Oxidative Metabolism to Restore Macrophage Function in COPD. E.M. Ryan, P. Sadiku, P. Coelho, E.R. Watts, A. Zhang, A.J.M. Howden, M.A. Sanchez-Garcia, M. Bewley, J. Cole, B.J. McHugh, W. Vermaelen, B. Ghesquiere, P. Carmeliet, G. Rodriguez Blanco, A. Von Kriegsheim, Y. Sanchez, W. Rumsey, J.F. Callahan, G. Cooper, N. Parkinson, K. Baillie, D.A. Cantrell, J. McCafferty, G. Choudhury, D. Singh, D.H. Dockrell, M.K.B. Whyte, S.R. Walmsley. American Journal of Respiratory and Critical Care Medicine. 2023 Feb 1. doi: 10.1164/rccm.202203-0482OC. Online ahead of print. PMID: 36724365
2022
Phagosomal acidification is required to kill Streptococcus pneumoniae in a zebrafish model. T.K. Prajsnar, B. Michno, N. Pooranachandran, A.K. Fenton, T.J. Mitchell, D.H. Dockrell, S. A. Renshaw. Cellular Microbiology. 2022 10.1155/2022/9429516
The prevalence of hypoxemia in children with pneumonia in low-income and middle-income countries: a systematic review and meta-analysis. A.E. Rahman, A.T. Hossain, H. Nair, M. J. Chisti, D. Dockrell, S. El Arifeen, H. Campbell. The Lancet Global Health 2022: 10; e348-359
2021
Pneumolysin is responsible for differential gene expression and modifications in the epigenetic landscape of primary monocyte derived macrophages. J. Cole, A. Angyal, R. D.Emes, T.J. Mitchell, M.J. Dickman, D.H. Dockrell. Frontiers Immunology 2021 12:573266. doi: 10.3389/fimmu.2021.573266
Neutrophil HIF-1α stabilisation is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle. J.A. Willson, S. Arienti, P. Sadiku, L. Reyes, …,, D.H. Dockrell, …, S. Walmsley. Blood. In press doi: 10.1182/blood.2021011010
The effect of live attenuated influenza vaccine on pneumococcal colonization densities among children aged 24-59 months in the Gambia – A phase IV, open label, randomized controlled trial. C. Penoa, E.P. Armitage, M. Clerca, C.L. Balcazara, Y.J. Jagneb, S. Drammehb, S. Jarjub, H. Sallahb, E. Senghoreb, B.B. Lindsey, J. Camara, S. Bah, N.I. Mohammed, D.H. Dockrell, B. Kampmann, E. Clarke, D. Bogaert & T.I. de Silva. The Lancet Microbe. 2021: 2; 2656-65
2020
Genome-wide CRISPR screen Identifies Host Dependency Factors for Influenza A Virus Infection. B. Li, S. Clohisey, B. S. Chia, B. Wang, …, D. Dockrell,…, and N. Hacohen. Nature Communications 2020: 11; 164
2019
Alveolar macrophage apoptosis-associated bacterial killing helps prevent murine pneumonia. J.A. Preston, M.A. Bewley, H.M. Marriott, A.M. Houghton, M. Mohasin, J. Jubrail, L. Morris, Y.L. Stephenson, S. Cross, D.R. Greaves, R.W. Craig, N. van Rooijen, C.D. Bingle, R.C. Read, T.J. Mitchell, M.K.B. Whyte, S.D. Shapiro and D. H. Dockrell. American Journal of Respiratory and Critical Care Medicine 2019: 200; 84-97 doi: 10.1164/rccm.201804-0646OC.PMID 30649895
2018
Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists. M.A. Bewley, R.C. Budd, E. Ryan, J. Cole,… and D. H. Dockrell. American Journal of Respiratory and Critical Care Medicine 2018: 198; 739-50 doi10/1164/rccm.201705-0903O
HIV gp120 in lungs of ART-treated individuals impairs alveolar macrophage responses to pneumococci. P.J. Collini, M.A. Bewley, M. Mohasin, H.M. Marriott,… and D. H. Dockrell. American Journal of Respiratory and Critical Care Medicine 2018: 197; 1604-15
